5-MeO-DMT is widely considered to be the most powerful psychedelic. This is not due to the dosages needed to reach intense altered states – technically, the most potent psychedelic in that respect is LSD, with Salvia divinorum being the most potent naturally occurring psychedelic, given that active doses of Salvinorin A are as low as…
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If we want to prioritise ‘set and setting’ (our mindset and physical and social environment) when using psychedelics, then we should be aware of all the possible aspects of our minds and the world that could influence the experience. Realistically, there are innumerable aspects of set and setting, many of which we won’t be aware…
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Nitrous oxide (‘laughing gas’) is a colourless gas with sedative, analgesic, euphoric, dissociative, and (if the dose is right) mystical effects. When used recreationally, the gas comes in canisters, known as ‘nangs’ in Australia and New Zealand, with other street names for the gas including ‘whippets’ (or ‘whippits’) and ‘hippy crack’. There is both a…
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People with a personal or family history of bipolar disorder (a condition marked by extreme mood swings) are typically excluded from being participants in psychedelic clinical trials. While research continues to show that psychedelic therapy, such as psilocybin therapy, is helpful for depression (which is an aspect of bipolar disorder), the mania that bipolar patients…
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Hallucinogen persisting perception disorder (HPPD) is a condition – characterised by chronic visual distortions – that can be triggered by psychedelics. It is considered a rare risk of psychedelic use, although the actual incidence of it is unknown (studies are limited and offer differing incidence rates). Many psychedelic users experience post-trip visual changes, but these…
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