Why Do Some People Develop HPPD and Not Others?

Hallucinogen persisting perception disorder (HPPD) is a rare condition that can develop after psychedelic use. HPPD involves persisting visual changes that cause emotional distress and/or impairment to functioning. It is not clear precisely how prevalent the condition is, although its prevalence is considered low. In one study, 4.2% of participants said they experienced continued visual…

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Understanding the Risks of 5-MeO-DMT

5-MeO-DMT is widely considered to be the most powerful psychedelic. This is not due to the dosages needed to reach intense altered states – technically, the most potent psychedelic in that respect is LSD, with Salvia divinorum being the most potent naturally occurring psychedelic, given that active doses of Salvinorin A are as low as…

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Some Psychedelic Users Are Unbothered by HPPD (and Might Even Enjoy It)

Hallucinogen persisting perception disorder (HPPD) is a condition – characterised by chronic visual distortions – that can be triggered by psychedelics. It is considered a rare risk of psychedelic use, although the actual incidence of it is unknown (studies are limited and offer differing incidence rates). Many psychedelic users experience post-trip visual changes, but these…

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‘How to Change Your Mind’ and the Destigmatisation of Psychedelics

The Netflix docuseries How to Change Your Mind, based on Michael Pollan’s book of the same name, explores the history and therapeutic effects of four different psychoactive compounds: LSD, psilocybin, MDMA, and mescaline (with the episodes in that order).  Directed by Alison Ellwood and Lucy Walker, and presented by Pollan, How to Change Your Mind…

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